Adenocarcinoma Arising in an Esophageal Duplication Cyst With Disseminated Metastases: A Rare Case Detected on 18 F-FDG PET/CT.

Narayanan, Sathya; Kumar, Srinivas Ananth; Goyal, Harish; Halanaik, Dhanapathi · Clin Nucl Med · 2026

case_report · Level V

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Abstract

Esophageal duplication cysts (EDCs) are rare congenital anomalies resulting from aberrant development of the posterior division of the primitive foregut. Malignant transformation of EDCs is exceptionally rare, with only a limited number of cases reported in the literature. The most commonly described histologic type in these transformations is adenocarcinoma. Herein, we report a case of an incidentally detected adenocarcinoma in an EDC with systemic metastases at initial presentation, in a patient with elevated tumor markers and strong clinical suspicion of underlying malignancy on 18 F-FDG PET/CT.

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