Regenerate to "Rejuvenate": Insights From Adult Resident Stem Cells of Aged Flatworms and Mice.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 40947308.
- Also identified by DOI 10.1111/acel.70236 and PMC identifier 12611277.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Adult resident stem cells are capable of regenerating tissues that manifest signs of "rejuvenation" in flatworms and mice of older ages. These findings suggest potentially conserved regulatory mechanisms of adult resident stem cells from worms to mammals. Regenerative capacities are more limited in specific tissues and stem cell types of larger mammals. Understanding and harnessing the rejuvenating properties of resident adult stem cells in flatworms and mice could have broad therapeutic implications for improving stem cell function and tissue plasticity across organ systems of humans in advanced age.
Medical subject headings
- Adult Stem Cells
- Regeneration
- Platyhelminths
- Aging
- Rejuvenation