Should We Embark on "EMBARK"? Reassessing the Role of Radiotherapy and Androgen Receptor Pathway Inhibitors in the Era of Next-generation Imaging.

Marvaso, Giulia; Francolini, Giulio; Achard, Vérane; Gomez-Iturriaga, Alfonso; Slevin, Finbar; Zilli, Thomas; Ost, Piet; Urology Focus Group of the European Society for Radiotherapy and Oncology · Eur Urol · 2026

review · Level V

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Abstract

Results from the EMBARK trial reshape the treatment paradigm for high-risk biochemical recurrence of prostate cancer. EMBARK data support the use of androgen receptor pathway inhibitors combined with metastasis-directed therapy in a personalized, multidisciplinary care approach for this subset of patients.

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