Can muscle avert GLP1R weight plateau and regain?
Where this comes from
- Record sourced from PubMed, PMID 40961927.
- Also identified by DOI 10.1016/j.xcrm.2025.102308 and PMC identifier 12490208.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
GLP1R-based obesity therapies can reduce lean muscle and energy expenditure via adaptive thermogenesis (also known as metabolic adaptation), leading to weight plateaus and regain. Defining the role of muscle energy expenditure in mediating these effects is critical to improving next-generation treatments and sustaining long-term weight loss.
Medical subject headings
- Muscle, Skeletal
- Obesity
- Glucagon-Like Peptide-1 Receptor
- Weight Gain