68 Ga-FAPI-04: A Powerful Tool for Detecting Subcentimeter Metastases of Intrahepatic Cholangiocarcinoma.

Sun, Yu; Jiang, Jianjun; Meng, Qingyuan; Wang, Weilun; Zhao, Jun · Clin Nucl Med · 2026

case_report · Level V

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Abstract

A 53-year-old woman presented with subcentimeter liver metastases 18 months after resection of intrahepatic cholangiocarcinoma. 18 F-FDG PET/CT imaging demonstrated no FDG avid in the lesions, whereas 68 Ga-FAPI-04 PET identified 3 metastases with high FAPI uptake. On conventional or contrast-enhanced MRI evaluation, each sequence detected just 1-2 lesions. Our case highlights the advantage and superior sensitivity of 68 Ga-FAPI-04 over 18 F-FDG and MRI in detecting subcentimeter metastases of intrahepatic cholangiocarcinoma.

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