A Zero-Thermal Quenching Flexible Fiber for Visible Cellular Concentration Detection.
basic_science · Level V
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- Record sourced from PubMed, PMID 40965219.
- Also identified by DOI 10.1002/adma.202513743.
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Abstract
The development of stable and precise visible light sources is crucial for advanced cellular analysis, yet current spectrophotometric systems face significant challenges, particularly temperature-dependent signal drift and decreased measurement accuracy. In this work, a novel yellow-emitting phosphor Gd<sub>3</sub>ScGa<sub>4</sub>O<sub>12</sub>: Dy<sup>3+</sup> is developed, which demonstrates exceptional thermal stability with zero-thermal quenching (ZTQ) up to 200 °C. This remarkable performance is achieved through the strategic manipulation of trap-assisted thermoluminescence enhancement mechanisms. In addition, a flexible optical detector is developed for oxyhemoglobin (HbO<sub>2</sub>) concentration testing by incorporating Gd<sub>3</sub>ScGa<sub>4</sub>O<sub>12</sub>: Dy<sup>3+</sup> in stretchable elastomer-based optical fiber. The fabricated device exhibits exceptional photoluminescence stability (near-zero chromaticity drift, Δx/y < 0.003 from 10 to 40 °C), and promising measurement accuracy (200 µg mL<sup>-1</sup>). Tb<sup>3+</sup>/ Eu<sup>3+</sup>/ Pr<sup>3+</sup> doped Gd<sub>3</sub>ScGa<sub>4</sub>O<sub>12</sub> is also developed, which all perform favorable thermal stability. This finding not only provides a reliable and reusable cellular concentration detector but also establishes a ZTQ design framework for lanthanide-doped materials.