Fasting Mimicking Diets Reverse Accelerated Biological Aging in Multiple Sclerosis.
rct · Level II
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- Record sourced from PubMed, PMID 40970462.
- Also identified by DOI 10.1002/ana.78044 and PMC identifier 12746903.
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Abstract
Reversing the aging process may yield significant benefits in people with multiple sclerosis (PwMS), as accelerated biological aging is observed in this population. Secondary analyses of 2 previously conducted dietary interventions including a 6-month modified ketogenic diet in 39 participants and an 8-week randomized comparison of intermittent and daily calorie restriction versus a weight-stable regimen in 36 participants demonstrated significant decreases in metabolomic age (mAge) following the ketogenic diet (p = 0.009) and intermittent calorie restriction (p = 0.04), whereas daily calorie reduction had no effect. These findings indicate that fasting-mimicking diets (FMDs) can reverse accelerated metabolomic aging in PwMS. ANN NEUROL 2025;98:1278-1282.
Medical subject headings
- Fasting
- Caloric Restriction
- Multiple Sclerosis
- Diet, Ketogenic
- Aging