Metabolite-enhanced normothermic machine perfusion improves kidney transplant viability.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40985893.
- Also identified by DOI 10.1172/jci.insight.190185 and PMC identifier 12487851.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Normothermic machine perfusion (NMP) has become a valuable tool to expand the pool of transplantable organs. However, the application of NMP to kidneys presents substantial challenges, mostly due to high variability in the composition of currently used perfusion solutions. Here, we provide a multimodal cross-species cellular atlas of kidney injury associated with NMP using a literature-based consensus buffer. This resource provided a systematic framework that was used to develop a metabolite-enhanced perfusion solution, which protected renal proximal tubular cells, improving cellular viability and transplantation outcomes across species, including human kidneys.
Medical subject headings
- Kidney Transplantation
- Perfusion
- Organ Preservation
- Organ Preservation Solutions