Adrenal Corticosteroids and Increased Intracranial Pressure in Nonimmunocompromised Patients With Cryptococcal Meningitis.

Bennett, John E; Anjum, Seher; Williamson, Peter R · J Infect Dis · 2026

case_series · Level IV

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Abstract

Elevated opening pressures on lumbar puncture were followed in 7 nonimmunocompromised patients being treated for a postinfectious inflammatory response syndrome that had begun following antifungal treatment of cryptococcal meningitis. During the initial period of high-dose corticosteroid therapy, opening pressures on lumbar puncture fell an average of 14 cm. Despite this, 5 of 7 patients later required a ventriculoperitoneal shunt for pressure control.

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