Pearls & Oy-sters: Acute Obstructive Hydrocephalus Co-Occurrence With Vigabatrin-Associated MRI Changes in an Infant With LIS1-Related Classical Lissencephaly.
case_report · Level V
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- Record sourced from PubMed, PMID 41004695.
- Also identified by DOI 10.1212/WNL.0000000000214181.
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Abstract
We present a case of a 4-month-old infant with classical type I lissencephaly treated with vigabatrin for hypsarrhythmia. The patient subsequently developed hypotonia and respiratory failure. Imaging revealed vigabatrin-associated brain abnormalities on MRI (VABAM), with acute obstructive hydrocephalus requiring emergent extraventricular drainage. VABAM involve a predictable pattern of restricted diffusion, are generally clinically silent, and are reversible on cessation of the medication. This case presents a rare, life-threatening complication in association with VABAM. In this report, we review the pathophysiology of this phenomenon and the potential influence of lissencephaly.
Medical subject headings
- Hydrocephalus
- Vigabatrin
- Anticonvulsants
- Classical Lissencephalies and Subcortical Band Heterotopias
- Lissencephaly