Elevation of tTG-IgA Antibodies in a Prospective Cohort of Children at Risk of Celiac Disease: Insights From the CDGEMM Cohort.
prospective_cohort · Level II
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- Record sourced from PubMed, PMID 41020645.
- Also identified by DOI 10.14309/ajg.0000000000003772 and PMC identifier 13037947.
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Abstract
Celiac disease (CeD) is a common immune-mediated condition that occurs in genetically predisposed individuals. In this study, we examined the trajectory of tissue transglutaminase IgA (tTG-IgA) antibodies in a prospective longitudinal cohort of over 500 children at risk of developing CeD due to having a first-degree relative with CeD. We identified 34 subjects from our cohort and examined tTG-IgA titers at seroconversion and 6 months before tTG-IgA seroconversion. We found that all subjects had normal tTG-IgA 6 months before seroconversion. Thus, we conclude that tTG-IgA elevation in subjects with CeD is a sudden event and its trajectory cannot be used as a marker to predict seroconversion in this population.
Medical subject headings
- Celiac Disease
- Transglutaminases
- Immunoglobulin A
- GTP-Binding Proteins
- Autoantibodies