Rare Presentation of Lymphomatoid Granulomatosis With CNS, Pulmonary, and Musculoskeletal System Involvement on 18 F-FDG PET/CT.

Purohit, Priyavrat; Preet, Komal; Mittal, Bhagwant R; Kumar, Rajender; Singh, Harmandeep; Bal, Amanjit; Malhotra, Pankaj · Clin Nucl Med · 2026

case_report · Level V

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Abstract

Lymphomatoid granulomatosis is an extralymphatic angio-invasive B-cell-associated lymphoproliferative disease. It primarily affects the lungs, followed by the skin, CNS, renal, and liver, and rarely involves the musculoskeletal system. Here we report a young man with pyrexia of unknown origin in whom FDG PET/CT demonstrated an unusual combination of CNS, lung, and musculoskeletal involvement mimicking diffuse metastasis. He was diagnosed with lymphomatoid granulomatosis, grade I, on a guided biopsy of the lung nodule.

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