Clonal hematopoiesis driven by Dnmt3a mutations promotes metabolic disease development in mice.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41027007.
- Also identified by DOI 10.1172/JCI197100 and PMC identifier 12646656.
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Abstract
#ClonalHematopoiesis, an #aging related condition caused by mutations in the #blood system, promotes #obesity, and with high-fat #diet drives the risk of #diabetes and #MASLD.
Medical subject headings
- Clonal Hematopoiesis
- DNA (Cytosine-5-)-Methyltransferases
- Mutation
- Metabolic Diseases