Profiling Human Papillomavirus Lineage-Specific Capsid Antigenicity With Geographically Diverse Natural Infection Antibodies.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41027580.
- Also identified by DOI 10.1093/infdis/jiaf502 and PMC identifier 12811858.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Human papillomavirus variants are classified into lineages based on their whole genome sequence, but the impact of lineage variation on the structure or function of encoded proteins is unclear. We used a global panel of lineage-specific natural infection sera to assess antibody-binding specificity for lineage-specific L1L2 antigens, and we used these data to create relational antigenic maps. Merging these data with neutralizing antibody data demonstrated similar spatial geometry and revealed dependency on a limited number of amino residues on the capsid surface. These data inform the degree of lineage specificity within the natural infection humoral immune response to oncogenic human papillomaviruses.
Medical subject headings
- Antibodies, Viral
- Capsid Proteins
- Papillomavirus Infections
- Papillomaviridae
- Antigens, Viral
- Capsid