Achieving handle-level random access in an encrypted DNA archival storage system via frequency dictionary mapping coding.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41040959.
- Also identified by DOI 10.1016/j.patter.2025.101288 and PMC identifier 12485530.
- Licence recorded as CC BY-NC-ND.
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Abstract
DNA storage provides a high storage density and durability, but current systems experience high latency and lack data security. This study proposed the use of frequency dictionary mapping coding (FDMC) to enable handle-level random access of DNA archival storage. In addition, a hybrid e-molecular encryption strategy and a multi-level error-correction algorithm were introduced to ensure data security and integrity. The simulation and wet experiment results demonstrated that FDMC achieved handle-level random access in a lossless encrypted DNA storage system, which balanced security and robustness. Even in extreme cases, in which there was a 10% loss of DNA sequences, this system still recovered 91.74% of the original data while ensuring a storage density above 1.80 bits per nucleotide. In summary, FDMC enhances the application potential of DNA as a storage medium and bridges the gap between DNA storage and traditional storage modes.