Building the start: Unlocking advanced stem cell-based embryo models.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41043397.
- Also identified by DOI 10.1016/j.stem.2025.08.016.
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Abstract
Two recent studies from the Silva and Hanna groups optimized chemical induction and culture conditions to derive extraembryonic lineages directly from embryonic stem cells (ESCs) without transgenes, enabling mouse stem cell-based embryo models (SCBEMs) to reproducibly advance to the E8.5-E8.75 stage.
Medical subject headings
- Embryo, Mammalian
- Embryonic Stem Cells
- Models, Biological
- Mouse Embryonic Stem Cells