Unmasking cancer's hidden nerve route with patient-derived organoids.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41043399.
- Also identified by DOI 10.1016/j.stem.2025.08.008.
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Abstract
Chan et al.<sup>1</sup> show that enteric neurons influence lipid metabolism in gastric cancer organoids, affecting dependencies on key enzymes. Using CRISPR screening and metabolic analysis, their work highlights how microenvironmental signals impact tumor metabolism and potential treatment targets in gastric cancer.
Medical subject headings
- Organoids
- Stomach Neoplasms