From sentinels to engineers: The future of microglia in brain regeneration.
review · Level V
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- Record sourced from PubMed, PMID 41043402.
- Also identified by DOI 10.1016/j.stem.2025.09.004 and PMC identifier 12895169.
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Abstract
Recent studies highlight microglial replacement as a promising therapeutic approach for neurological disease. Wu et al.<sup>1</sup> demonstrated that transplanted bone marrow-derived cells halted ALSP progression, while Mader et al.<sup>2</sup> introduced a strategy that avoids systemic bone marrow ablation toxicity and reduces immune rejection, collectively validating this strategy's therapeutic potential.
Medical subject headings
- Microglia
- Brain
- Regeneration