Updated Surgical Technique for Implantation of Revakinagene Taroretcel.

Abstract

Present an updated technique for surgical implantation of revakinagene taroretcel. The surgical technique is described with supplemental video included. Surgical implantation of revakinagene taroretcel was safely performed without adverse events. The capsule was positioned into the vitreous cavity, the associated fixation loop was appropriately secured to the sclera using a double-armed 9-0 polypropylene suture, the sclerotomy was closed with 9-0 nylon sutures, and the conjunctiva was closed to ensure proper coverage of the sutures and insertion site. The described surgical implantation technique was developed using learnings from the associated Phase 2 and 3 trials and implemented to maximize the likelihood of long-term capsule stability and minimize the risk of adverse events including device extrusion.