Powering the heart: fully bioresorbable epicardial pacing leads.

Abstract

Conventional temporary epicardial pacing wires (TPWs) are widely used for postoperative pacing support but pose risks of several complications due to their non-biodegradable nature. Here we present a fully bioresorbable epicardial pacing lead composed of a pure zinc (Zn) core and a bioresorbable polymer insulation coating, fabricated using a simple and scalable dip-coating method. Zn-based leads demonstrated reliable pacing performance over a 4-week period in a rabbit model, comparable to clinical benchmarks. Comprehensive evaluations of their degradation behavior and tissue response in animal models revealed stable bioresorption and acceptable biocompatibility during and after the therapeutic period. This bioresorbable design eliminates the risks associated with non-degradable TPWs, while maintaining therapeutic efficacy and biocompatibility. With its unique combination of performance, safety, and adaptability, the Zn-polymer pacing lead represents a transformative step toward the next generation of TPWs, offering a safer and more effective alternative for managing postoperative cardiac pacing.