Mitochondrial sodium-calcium exchange-Can TMEM65 do it alone?
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 41061666.
- Also identified by DOI 10.1016/j.cmet.2025.09.005 and PMC identifier 12914696.
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Abstract
The mechanisms mediating calcium transport into and out of the mitochondrial matrix have critical implications for signaling, bioenergetics, and cell death. Zhang et al.<sup>1</sup> propose that the protein TMEM65, recently identified as a key component of the mitochondrial calcium efflux machinery, functions as the mitochondrial sodium/calcium exchanger. Their report encourages critical re-examination of the components required for mitochondrial calcium handling.
Medical subject headings
- Sodium-Calcium Exchanger
- Calcium
- Mitochondria
- Membrane Proteins
- Mitochondrial Proteins