An "electric" microbial cue to control food intake behavior.

Li, Huixian; Mucida, Daniel · Cell Metab · 2025

basic_science · Level V

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Abstract

The gut conveys nutritional, mechanical, and microbial signals to the brain to regulate physiology and behavior. Writing in Nature, Liu et al. reveal a colonic neuropod-vagus circuit that senses bacterial flagellin, highlighting microbial input as a rapid driver of feeding control and expanding paradigms of communication between the gut and the brain.

Medical subject headings