A human pan-disease blood atlas of the circulating proteome.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 41066540.
- Also identified by DOI 10.1126/science.adx2678.
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Abstract
The human blood proteome provides a holistic readout of health states through the assessment of thousands of circulating proteins. In this study, we present a pan-disease resource to enable the study of diverse disease phenotypes within a harmonized proteomics dataset. By profiling protein concentrations across 59 diseases and healthy cohorts, we identified proteins associated with age, sex, and body mass index, as well as disease-specific signatures. This study highlights shared and distinct protein patterns across conditions, demonstrating the power of a unified proteomics approach to uncover biological insights. The dataset, covering 8262 individuals and up to 5416 proteins, serves as an online resource for exploring disease-specific protein profiles and advancing precision medicine research.
Medical subject headings
- Blood Proteins
- Disease
- Proteome
- Atlases as Topic