Structural basis of measles virus polymerase inhibition by nonnucleoside inhibitor ERDRP-0519.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41083444.
- Also identified by DOI 10.1038/s41467-025-64128-0 and PMC identifier 12518664.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
ERDRP-0519 is a potent nonnucleoside inhibitor active against measles virus (MeV) and other Morbilliviruses. Here we report cryo-EM structures of the compound bound to MeV polymerase complexes at 2.73 Å and 2.48 Å resolution, revealing a unique binding pocket in the RdRp palm subdomain that overlaps the catalytic GDN motif. These findings clarify the basis of resistance mutations, including W671, and provide a foundation for designing next-generation Paramyxovirus antivirals.
Medical subject headings
- Measles virus
- Antiviral Agents
- RNA-Dependent RNA Polymerase
- Enzyme Inhibitors
- Viral Proteins