Bio-hybrid photoelectrochemical catalysis for solar fuels and chemicals conversion.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41087385.
- Also identified by DOI 10.1038/s41467-025-64931-9 and PMC identifier 12521356.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Bio-hybrid photoelectrochemical (PEC) devices integrate the complementary advantages of both biocatalyst and abiotic components, providing opportunities for efficient catalysis under mild conditions with high selectivity and low over-potential. However, the practical applications of such devices depend on the stability and efficiency of the bio-abiotic interface, where suboptimal charge transfer, biocatalyst fragility, and scalability challenges persist. In this Perspective, we evaluate established strategies for wiring biocatalysts to electrode substrates within bio-hybrid PEC architectures, analyze their catalytic performance, and operational limitations, and underly mechanistic principles. Then, we highlight the integration of whole-cell biocatalysts with high-performance semiconductor scaffolds as a promising design paradigm, offering a scalable platform for sustainable, solar-driven chemical production.