Beyond anticholinergic effects: A case of trihexyphenidyl-induced bradycardia.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 41089938.
- Also identified by DOI 10.4103/jfmpc.jfmpc_113_25 and PMC identifier 12517587.
- Licence recorded as CC BY-NC-SA.
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Abstract
Anticholinergic drugs are extensively employed in clinical settings, with their side effects well-documented. However, paradoxical bradycardia due to trihexyphenidyl hydrochloride, an anticholinergic agent, is an infrequent and underreported phenomenon. This may be attributed to a lack of vigilant monitoring in patients undergoing therapy. Here, we present the case of a 12-year-old girl who developed sinus bradycardia following the administration of trihexyphenidyl. The heart rate normalized upon drug discontinuation. This report emphasizes the need for thorough cardiac monitoring, including baseline heart rate, Electrocardiogram (ECG), and electrolyte evaluation, before initiating therapy to prevent adverse outcomes.