Drug adherence attitude in patients with bipolar disorder and unipolar depression: Insights from a cross-sectional study in central India.

Abstract

Medication adherence in patients with unipolar depression and bipolar disorder is a critical factor influencing treatment outcomes. Despite remission, medication adherence remains a challenge, with various clinical and sociodemographic factors potentially affecting patient attitudes toward drug compliance. Understanding these factors can help tailor interventions to improve adherence and provide a better primary care. The aim of this study was to assess drug adherence attitudes and identify factors influencing adherence in patients with unipolar depression and bipolar disorder currently in remission. This cross-sectional study was conducted with patients diagnosed with unipolar depression and bipolar disorder in remission. Sociodemographic and clinical variables were collected through structured interviews. Drug adherence was measured using the Drug Adherence Inventory scale. Statistical analyses were performed to identify factors correlating with drug adherence. The study found that older age, male gender, and formal education were significantly associated with better drug adherence. Clinically, a higher number of episodes were linked to improved adherence as patients with more episodes demonstrated better compliance. Other clinical factors, including comorbidities and medication type, did not significantly impact adherence attitudes. The study highlighted the importance of sociodemographic factors in shaping drug adherence. Sociodemographic factors, particularly age, gender, and education, play a significant role in medication adherence among patients with unipolar depression and bipolar disorder. The number of episodes also positively impacts adherence, suggesting that patients with frequent episodes may develop stronger commitment to treatment. Targeted interventions, addressing these factors, could improve medication adherence and patient outcomes in these populations. Further research is needed to explore personalized approaches for enhancing drug adherence.