The geroprotective potential of chalcones.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 41093833.
- Also identified by DOI 10.1038/s41467-025-64167-7 and PMC identifier 12528369.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Aging is the most important risk factor for multiple pathologies including cardiovascular, neoplastic, metabolic and neurodegenerative diseases. Potential geroprotective strategies involve lifestyle-related, nutritional and pharmacological interventions. Recently, chalcones, a subgroup of secondary plant metabolites, have gained attention. 4,4'-dimethoxychalcone was the first chalcone to be shown to mediate geroprotection and lifespan extension across different species. Several other chalcones also exert anti-aging effects at the cellular and organismal levels. Defined mechanistic routes that are causally involved in these protective effects have been delineated. Here, we summarize current evidence supporting the potential of 4,4'-dimethoxychalcone and other chalcones as geroprotective agents.
Medical subject headings
- Chalcones
- Aging
- Protective Agents