The 2025 Centers for Disease Control and Prevention Nonoccupational HIV Postexposure Prophylaxis Guidelines: Updated Regimens and Remaining Questions.

Allan-Blitz, Lao-Tzu; Mayer, Kenneth H · Clin Infect Dis · 2026

review · Level V

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Abstract

The United States Centers for Disease Control and Prevention recently released updated guidance on nonoccupational human immunodeficiency virus postexposure prophylaxis. The guidelines introduce coformulated antiretrovirals as a preferred regimen, which will likely positively impact prescribing practices and adherence. However, other barriers to access and uptake remain a challenge.

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