Adult neurogenesis reconciles flexibility and stability of olfactory perceptual memory.

Abstract

In brain regions featuring ongoing plasticity, the task of quickly encoding new information without overwriting old memories presents a significant challenge. In the rodent olfactory bulb, which is renowned for substantial structural plasticity driven by adult neurogenesis and persistent turnover of dendritic spines, we show that by synergistically combining both types of plasticity, this flexibility-stability dilemma can be overcome. To do so, we develop a computational model for structural plasticity in the olfactory bulb and show that it is the maturation process of adult-born neurons that enables the bulb to learn quickly and forget slowly. Particularly important are the transient enhancement of the plasticity, excitability, and susceptibility to apoptosis that characterizes young neurons. The model captures many experimental observations and makes a number of testable predictions. Overall, it identifies memory consolidation as an important role of adult neurogenesis in olfaction and exemplifies how the brain can maintain stable memories despite ongoing extensive neurogenesis and synaptic plasticity.