Metabolic heavyweight: thick ascending limb or proximal tubule? Next round.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 41110887.
- Also identified by DOI 10.1016/j.kint.2025.08.010.
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Abstract
In this issue of Kidney International, investigators define the thick ascending limb as the most metabolically active cell in the kidney using a combination of single-cell techniques and mass spectrometry imaging with stable isotope tracing studies. They show that the thick ascending limb is particularly susceptible to acute kidney injury and resistant to repair. These data are discussed in the context of the longstanding debate regarding the relative roles of thick ascending limb and proximal tubules in acute kidney injury.
Medical subject headings
- Kidney Tubules, Proximal
- Acute Kidney Injury
- Loop of Henle