Direct Therapeutic Modulation of RYR2 Activity by CMYA5.

Lu, Fujian; Wu, Zexuan; Chi, Shaopeng; Wang, Yangong; Ponek, Anna; Ma, Qing; Chen, Chunjing; Shi, Bingbing et al. · Circulation · 2025

basic_science · Level V

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Record sourced from PubMed, PMID 41115167.
Also identified by DOI 10.1161/CIRCULATIONAHA.125.075402 and PMC identifier 12616379.
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A domain of CMYA5 (RID) is a novel RYR2 regulator. RID overexpression reduced arrhythmias in CPVT disease models.