Apolipoprotein A-IV fibrils: structural diagnosis of mixed cardiac amyloidosis.
Where this comes from
- Record sourced from PubMed, PMID 41115976.
- Also identified by DOI 10.1038/s41467-025-64902-0 and PMC identifier 12537937.
- Licence recorded as CC BY-NC-ND.
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Abstract
Cardiac amyloidosis (CA) occurs when misfolded proteins deposit as fibrils in the extracellular space of the heart. The fibrillogenic properties of apolipoprotein A-IV (ApoAIV) have been histologically observed and associated with CA pathogenesis. We report the structure of an ApoAIV amyloid from a patient's heart, which coexist amongst transthyretin (TTR) amyloids. These cases of undetected mixed CA highlight the importance of developing broad-spectrum anti-amyloid treatments to improve outcomes in patients.
Medical subject headings
- Amyloid
- Amyloidosis
- Apolipoproteins A
- Cardiomyopathies
- Myocardium