Blood Pressure After Changes in Light-to-Moderate Alcohol Consumption in Women and Men: Longitudinal Japanese Annual Checkup Analysis.

Abstract

Alcohol consumption is a known contributor to elevated blood pressure (BP). However, the association between changes in light-to-moderate alcohol consumption (eg, ≤1 drink for women and ≤2 drinks for men daily), especially cessation, and BP remains unclear. In this study, the authors sought to evaluate the associations between alcohol cessation/initiation and subsequent BP changes, focusing on sex-specific estimates, light-to-moderate intake, and type of alcoholic beverage. We analyzed data from adults undergoing annual health checkups at a Japanese preventive medicine center from October 2012 to March 2024. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) changes between consecutive visits were evaluated. Alcohol intake was self-reported as standard drinks (1 drink = 10 g ethanol). Associations between alcohol cessation/initiation and BP changes were assessed with the use of generalized estimating equations, adjusted for demographics, clinical history, and lifestyle behaviors. Among 359,717 visits from 58,943 participants, the cessation cohort (53,156 visits, 25,621 participants, median age 50.5 years, 52.1% women) revealed that cessation was associated with dose-dependent reductions in BP. Among women, cessation of 0.5 to 1.0 drinks per day did not correspond to a statistically significant change in SBP (-0.44 mm Hg; 95% CI: -0.93 to 0.06 mm Hg) and corresponded to a change of -0.41 mm Hg (95% CI: -0.77 to -0.05 mm Hg) in DBP, and cessation of 1.0 to 2.0 drinks per day corresponded to changes of -0.78 mm Hg (95% CI: -1.53 to -0.04 mm Hg) in SBP and -1.14 mm Hg (95% CI: -1.68 to -0.61 mm Hg) in DBP. Among men, cessation of 0.5 to 1.0 drinks per day did not correspond to a statistically significant change in SBP (-0.27 mm Hg; 95% CI: -0.81 to 0.27 mm Hg) or DBP (-0.39 mm Hg; 95% CI: -0.77 to 0.01 mm Hg), and cessation of 1.0 to 2.0 drinks per day corresponded to changes of -1.03 mm Hg (95% CI: -1.70 to -0.35 mm Hg) in SBP and -1.62 mm Hg (95% CI: -2.11 to -1.12 mm Hg) in DBP. The initiation cohort (128,552 visits, 31,532 participants, median age 50.0 years, 70.4% women) demonstrated dose-dependent increases in BP after alcohol initiation, and the overall direction of the effect was consistent across sexes. Beverage-specific analyses revealed similar BP effects regardless of alcohol type in both cohorts. Even at low levels, drinking was associated with higher BP, and cessation was associated with lower BP in both sexes. These findings suggest that alcohol cessation is a broadly applicable strategy even among light-to-moderate drinkers for BP management. In this large dataset, BP changes in women associated with consumption at levels as low at 0.5 to 1 drinks per day are detectable.