Global, Regional, and National Disparities in the Burden of Acute Pancreatitis and Alcohol-Related Pancreatitis From 2000 to 2021.

Abstract

To provide updated estimates of the global burden of acute pancreatitis (AP) as a major cause of hospital admissions for gastrointestinal diseases, which has a varied burden worldwide. The Global Burden of Disease Study 2021 was assessed to retrieve incidence, death, and age-standardized incidence (ASIR) and death (ASDR) rates for AP from 2000 to 2021. We also focused on the ASDR for AP from alcohol use. In 2021, the burden of AP accounted for 2.75 million cases with 122,420 deaths. Eastern Europe exhibited the highest burden. From 2000 to 2021, there was a decline in ASIR (annual percentage change [APC], -0.25%; 95% CI, -0.26% to -0.25%) and ASDR (APC, -0.75%; 95% CI, -0.90% to -0.59%). However, ASIR increased in low (APC, 0.06%; 95% CI, 0.05 to 0.06%), low-middle (APC, 0.19%; 95% CI, 0.18% to 0.20%), and middle (APC, 0.14%; 95% CI, 0.13% to 0.15%) sociodemographic index countries. Globally, 65 of 204 countries have undergone an increase in ASIR from AP. The ASDR for alcohol-related AP decreased worldwide but increased in low (APC, 1.48%; 95% CI, 1.37% to 1.59%), low-middle (APC, 1.63%; 95% CI, 1.36% to 1.90%), and middle (APC, 0.75%; 95% CI, 0.54% to 0.96%) sociodemographic index countries. A substantial increase in the global burden of AP affected one-third of countries, particularly those with lower socioeconomic development, necessitating efforts to mitigate its risk factors, one of which is alcohol consumption.