Netrin-1: pioneering new Frontiers in peripheral nerve injury treatment.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 41124081.
- Also identified by DOI 10.1093/postmj/qgaf080.
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Abstract
The incidence of peripheral nerve injury has increased annually and it has become a common traumatic disease in clinical practice. Netrin-1 is a crucial extracellular matrix protein that plays a significant role in nerve development and regeneration, and is involved in the construction of a local neurological injury regional regeneration and repair microenvironment to support axon and myelin repair growth. Recent studies have highlighted its important roles in the repair of peripheral nerve injuries. This review clarifies how Netrin-1 in fluences neuronal survival, promotes axonal regeneration, and modulates neuro-inflammation.
Medical subject headings
- Netrin-1
- Peripheral Nerve Injuries
- Nerve Regeneration