Segmental cholestasis drives global hepatic fibrosis: lessons from the sBDL model in weaned rats.
other · Level V
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- Record sourced from PubMed, PMID 41125961.
- Also identified by DOI 10.1038/s41390-025-04526-8.
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Abstract
This commentary provides a detailed analysis of Gonçalves et al.'s research paper, "Key genes and histopathological alterations in hepatic fibrogenesis after segmental cholestasis in weaned rats.<sup>1</sup>" It emphasizes how segmental cholestasis caused by selective bile duct ligation in young rats leads to extensive hepatic fibrogenesis, affecting both obstructed and non-obstructed liver lobes-similar to pediatric cholangiopathies like biliary atresia and post-transplant strictures in children. It not only illustrates regional hepatic disease patterns but also offers a valid preclinical platform for testing antifibrotic treatments.
Medical subject headings
- Cholestasis
- Liver Cirrhosis