Distinct human small intestinal microbiome communities underlie visceral hypersensitivity in a humanized mouse model.

Comba, Isin Y; Louwies, Tijs; Mars, Ruben At; Xiao, Yang; Sekhon, Prabhjot Kaur; Edwards, Brian S; Willits, Adam; Shields-Cutler, Robin R et al. · J Clin Invest · 2025

basic_science · Level V

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Abstract

Specific small-intestinal bacteria, particularly Enterobacteriaceae, can trigger abdominal pain by activating gut sensory and nerve cells, revealing how microbiota contribute to gastrointestinal symptoms.

Medical subject headings