Triple Tracer Heterogeneity in Dual Neoplasia: The "Three Musketeers" in Discerning Squamous Cell Carcinoma and Paraganglioma in the Same Patient.
case_report · Level V
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- Record sourced from PubMed, PMID 41129749.
- Also identified by DOI 10.1097/RLU.0000000000006149 and PMC identifier 13132081.
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Abstract
Head and neck squamous cell carcinoma of unknown primary (HNSCCUP) comprises 2%-5% of head and neck squamous cell cancers (HNSCC). Its coexistence with abdominal paraganglioma is exceedingly rare. We report a unique case of a 48-year-old male with HNSCCUP presenting as cervical lymphadenopathy and a coexisting abdominal paraganglioma. 18 F-FDG showed uptake in both lesions, while 68 Ga-DOTATATE was avid only in paraganglioma, and 68 Ga-DOTA-FAPI-04 was avid only in cervical nodes. These differential uptake patterns reflect distinct tumor biology and underscore the potential for tailoring theranostic treatment strategies with 177 Lu/ 90 Y isotopes for FAPI-avid squamous cell cancers (SCC) and DOTATATE-avid paragangliomas.
Medical subject headings
- Paraganglioma
- Carcinoma, Squamous Cell