Insights into the Complex Relationship Between Domain-Specific Physical Activity, Sedentary Behavior and Mortality in Adults with Chest Pain in the US.

Abstract

To assess the association between domain-specific physical activity (physical activity, PA; occupation-related PA, OPA; transportation-related PA, TPA; leisure-time PA, LTPA) and sedentary behavior and mortality among participants with chest pain. Cohort observational studies examined the associations between domain-specific PA and sedentary behaviors with mortality among participants with chest pain, adjusting for age, sex, race, and other medical comorbidities among chest pain adults (the National Health and Nutrition Examination Survey [NHANES]). Community setting. Participants aged 40 to 80 years were asked by well-trained staff whether they had ever felt pain or discomfort in their chest. If the answer was yes, they were diagnosed with chest pain. This study included 4,412 participants with complete data who had chest pain; their average age was 57.99 ± 0.26 years, and 51.90% (2,283) of them were female. None. Domain-specific physical activity (OPA, TPA, LTPA) and sedentary behaviors were assessed by using the Global Physical Activity Questionnaire, categorizing participants by 2018 physical activity guidelines and daily sitting time. Mortality outcomes (all-cause and cardiovascular) were determined via National Death Index records linked to ICD-10 codes up to December 2019. Among chest pain participants, higher levels of total or domain-specific PA were associated with reduced all-cause and cardiovascular-related mortality risks. Conversely, sitting time exceeding 480 minutes daily significantly increased these risks. Regular leisure-time PA mitigated mortality risks, even with mortality risk associated with sedentary behaviors. In adults with chest pain, regular leisure-time physical activity proved more effective than weekend warrior patterns in reducing mortality risks and mitigating the mortality risk token by sedentary behaviors.