The potential of TDP-43 PET ligands for a biological diagnosis of TDP-43 proteinopathies.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41136380.
- Also identified by DOI 10.1038/s41467-025-64541-5 and PMC identifier 12552723.
- Licence recorded as CC BY-NC-ND.
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Abstract
Candidate PET ligands targeting pathological TDP-43 aggregates are characterized by Vokali and colleagues in a series of human tissue, cell/animal model, and non-human primate experiments. Their preclinical data suggests favorable specificity and pharmacokinetic profiles of their two candidate tracers, which could translate into a disease-specific biomarker in TDP-43 proteinopathies.