Optoacoustic-Guided Magnetic Microrobot Platform for Precision Drug Delivery.

Abstract

Precision drug delivery remains a significant challenge due to limitations in drug loading, targeted release, precise navigation, and real-time monitoring. Here, the study reports a magnetic microrobot platform (MMP) that integrates high-capacity drug loading, magnetically actuated collective navigation, controlled drug release, and real-time 3D optoacoustic imaging in a single system. The MMP exploits synergistic advantages by embedding hard-magnetic FePt nanoparticles in a degradable ZIF-8 shell, achieving a drug loading efficiency of ≈93.9% and enabling precise release in response to pH changes and radiofrequency-induced heating. Reconfigurable swarm behavior strategies significantly enhance the navigation efficiency of microrobots against physiological blood flows within complex cerebral vasculature. The ex vivo and in vivo experiments further demonstrate strong contrast characteristics of the microrobots, enabling high-resolution visualization of deep vascular structures and dynamic tracking of MMP with real-time 3D optoacoustic imaging. This multifunctional strategy paves the way for clinical translation and precision therapy in complex biological settings.