Expression of serum ferroptosis related index PTGS2 in patients with traumatic arthritis and its correlation with secondary cartilage injury and diagnostic efficiency analysis.

Abstract

BackgroundTraumatic arthritis leads to progressive cartilage degeneration, ultimately causing joint dysfunction. Due to cartilage's limited ability to self-repair, damage often extends to bone and joint tissues. This study investigates the correlation between prostaglandin-endoperoxide synthase 2 (PTGS2) expression and cartilage injury in traumatic arthritis, aiming to assess PTGS2 as a potential biomarker for early diagnosis.MethodsWe analyzed data from 181 patients diagnosed with traumatic arthritis between January 2022 and August 2024. Serum levels of PTGS2 and cartilage biomarkers were measured and compared between patients with and without cartilage injury. Logistic regression and ROC curve analysis were used to evaluate the diagnostic efficacy of PTGS2.ResultsPTGS2 levels were significantly higher in patients with cartilage injury compared to those without (<i>p</i> < 0.05). Correlation analysis showed that PTGS2 was positively correlated with cartilage biomarkers (COMP, CTX-II) and identified as an independent risk factor for cartilage injury. ROC analysis revealed that PTGS2 had good diagnostic performance with an AUC of 0.820, sensitivity of 94%, and specificity of 68.42%.ConclusionPTGS2 is a promising biomarker for diagnosing cartilage injury in post-traumatic osteoarthritis and may serve as a target for early diagnosis and treatment.