Safety of Direct Amoxicillin Challenges to Evaluate Penicillin Allergy in Infants and Toddlers.

Tiano, Rasa; Ruan, Ellen; Shah, Devangi; Chow, Timothy G; Rukasin, Christine Rf · J Pediatr · 2026

retrospective_cohort · Level III

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Abstract

In a retrospective cohort from two pediatric referral centers, we demonstrate that direct amoxicillin challenges appear to be safe in infants and toddlers with a nonhigh risk penicillin allergy label. Our data support expanding the benefits of early penicillin allergy delabeling to this population.

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