An eNOS-like nanomaterial for specific reversal of cerebral ischemia-reperfusion injury.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 41145439.
- Also identified by DOI 10.1038/s41467-025-64518-4 and PMC identifier 12559320.
- Licence recorded as CC BY-NC-ND.
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Abstract
The protective role of NO has been widely verified in cerebrovascular diseases. However, the beneficial effects of NO depend on its concentration and reactive oxygen species (ROS) level, which makes current NO donors face great difficulties in treating cerebral ischemia-reperfusion injury (CIRI). Here, a tailored MoS<sub>2</sub>-based NO donor (MSNO) was constructed with defect-rich MoS<sub>2</sub>, in which the abundant S edge sites in the defects form -SNO, and the Mo sites can also bind NO to form Mo-NO. Combined with MSNO's own strong ability to eliminate ROS, MSNO could provide pure NO at suitable concentrations like eNOS and avoid the generation of highly toxic ONOO<sup>-</sup>. After intravenous injection, MSNO with suitable nano-size could penetrate the blood-brain barrier of ischemia-reperfusion injured brain tissue, and effectively treat CIRI through multiple effects: inhibiting calcium overload, alleviating mitochondrial damage and endoplasmic reticulum stress, and inhibiting the inflammatory storm.
Medical subject headings
- Reperfusion Injury
- Nanostructures
- Nitric Oxide Synthase Type III
- Brain Ischemia
- Nitric Oxide Donors