On the Road to ROME: Defining Tissue-Liquid Concordance in Precision Oncology.

Saldanha, Erick F; Siu, Lillian L · Clin Cancer Res · 2026

editorial · Level V

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Abstract

A growing body of evidence has established liquid biopsy as a promising, noninvasive platform for genomic profiling. In this commentary, we build on findings from the multicenter, randomized phase II ROME trial and interrogate the challenges and opportunities of tissue-liquid profiling concordance in improving personalized cancer treatment and survival outcomes. See related article by Botticelli et al., p. 45.

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