Impact of discontinuation of contact precautions on healthcare-associated ESBL-producing Escherichia coli in a large tertiary care hospital: an interrupted time-series analysis.

Musumeci, Stefano; Grant, Rebecca; Sobel, Jonathan; Cherkaoui, Abdessalam; Buetti, Niccolò; Harbarth, Stephan · Clin Infect Dis · 2025

retrospective_cohort · Level III

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Abstract

At Geneva University Hospitals, contact precautions for ESBL-producing Escherichia coli were discontinued in 2019. Among 2,336 hospital-associated cases from 2016 to 2024, incidence was 3.1 per 10,000 patient days at baseline and showed no significant increase after discontinuation (slope change -0.04, p=0.14). Results were consistent when limited to clinical isolates.