Gut Microbiota Predicts the Risk of Future COVID-19 Hospitalization and Mortality: Insights From the Population-Based HELIUS Study.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 41169175.
- Also identified by DOI 10.1093/infdis/jiaf541 and PMC identifier 13017446.
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Abstract
Gut microbiota are disrupted in patients hospitalized for COVID-19, with a loss of anaerobic bacteria-producing butyrate. Yet, these disruptions could either be a consequence of the infection itself or increase susceptibility from the outset. Here, we investigated whether gut microbiota influence the risk of future COVID-19 hospitalization and mortality. In 5084 participants of a population-based cohort, gut microbiota composition was associated with the risk of future severe COVID-19. Specifically, increased abundances of butyrate-producing bacteria were associated with a lower risk of severe COVID-19. Together, gut microbiota alterations precede severe COVID-19 and may represent a novel target for prevention.
Medical subject headings
- COVID-19
- Gastrointestinal Microbiome
- Hospitalization