Structural immunotherapy: Harnessing chemical design to build powerful next-generation therapeutics.
Level V
Where this comes from
- Record sourced from PubMed, PMID 41183192.
- Also identified by DOI 10.1073/pnas.2409553122 and PMC identifier 12625970.
- Licence recorded as CC BY-NC-ND.
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Abstract
Structural immunotherapy relies on the structural features of immunotherapeutics in addition to component identity to influence biodistribution, intra- or extracellular localization, target engagement, and processing kinetics. This strategy is poised to redefine how immunotherapeutics mobilize immunity against disease and transform our ability to harness structure-function relationships to enhance clinical outcomes.
Medical subject headings
- Immunotherapy
- Drug Design