Lipoprotein(a) in clinical practice: What clinicians need to know.

Al-Dalakta, Astefanos; Cho, Leslie S; Sarraju, Ashish · Cleve Clin J Med · 2025

review · Level V

Where this comes from

Abstract

Elevated lipoprotein(a) is an independent risk factor for atherosclerotic cardiovascular disease and aortic valve stenosis. Current lipid-lowering treatments have a minimal impact on lipoprotein(a) levels, but emerging therapies show promise, and ongoing phase 3 trials are evaluating their effect on cardiovascular outcomes. This review summarizes evidence on risk, screening strategies, and evolving therapies for elevated lipoprotein(a).

Medical subject headings